Abstract: By using one year surface observational data of 8 automatic and 3 artificial weather stations of different altitude in eastern and western slope of Mt.Seqilha over Tibet, the seasonal climatic features of air temperature, soil temperature, precipitation, humidity and wind speed have been analyzed.The reason of local climate difference between eastern and western slope of Mt.Seqilha have been discussed.The results show that:the coldest month is January and the warmest month is July in Mt.Seqilha.The seasonal change of daily maximum temperature, daily minimum temperature and daily mean temperature is consistent.The daily range of air temperature is large, but annual range is small.The lapse rate of annual mean temperature of eastern slope is smaller than that of western slope, which is 0.54℃/100m and 0.73℃/100m in eastern and western slope.The temperature difference between surface and air of western slope is larger than that of eastern slope in winter, but it's reverse in summer.The lapse rate of annual and monthly mean soil temperature of eastern slope is smaller than that of western slope too.The lapse rate of soil temperature of eastern slope is smaller than that of air temperature except July and August.But the lapse rate of soil temperature of western slope is larger than that of air temperature except December and January.The precipitation of eastern slope is more than that of western slope.The precipitation has an ascending trend with the more altitude on top of 2500m.when the altitude increases 100m, the precipitation increases 20.9mm.The air humidity is low in winter and high in summer, whose annual change is unmoral distribution.The wind speed of eastern and western slope in winter is both weaker than in summer, which is largest in early spring.The climatic differences between eastern and western slope is in relation to altitude, slope way and underlying surface property.