Abstract: The clinic data are collected from a hospital in Chengdu，together with the environmental monitoring data and atmospheric data during that period to make statistical analysis．The results show that the meteorological conditions have obvious influence on air pollution，in the absence of rainfall，wind speed is small，low visibility conditions，air pollution concentration is high，the air quality is poor．Air pollution has obvious effect on respiratory disease，and the effect of lower respiratory disease incidence is more remarkable．The impact of air pollution on upper respiratory disease has two days of lag，and the impact of lower respiratory disease generally have three or seven days lag．To upper respiratory disease，the impact of PM₁₀is most remarkable．The effects of NO₂，PM₁₀，PM_2.5and SO₂on the lower respiratory disease are significantly positive correlation，among which the most remarkable effect of SO₂．