Abstract: In this paper, the diffuse transport of industrial emission PM10 in Liangshan YI Autonomous Prefecture in 2007 was simulated by CALPUFF coupled with the MM5 model.The space-time distribution of pollutant concentration and its main influencing factors were analyzed.Resultsshow that CALPUFF coupled with the MM5 model is applicable to simulate the concentration of industrial emission PM10 in Liangshan.The pollutant is diffused mainly along the Anning River and Heishui River, and the distributive characteristics of concentration change along with variation of time, pollution is more serious in winter.The concentration is higher in Xichang and Ganluo, their season-average-concentration is 67.81μg/m3 and 57.23μg/m3, respectively.Affected by the weather conditions, terrain and geographical distribution of sources, spatial differentiation of PM10 concentration exists among study areas.