Abstract: Based on the daily meteorological data from 33 national terrestrial meteorological observation stations in Sichuan Province in recent 50 years, according to the altitude difference of different stations, the climate comfort in Sichuan Province was effectively corrected by using entropy method, distance method and percentile method, and the prediction model of climate comfort index in different seasons was established. The results show that: (1) From the point of view of the uncorrected comprehensive climate comfort index, except for some areas of the western Sichuan Plateau, Sichuan Province is more comfortable or comfortable in spring and autumn. In addition to the eastern part of the Basin, Sichuan Province has a good climate comfort in summer due to the cool weather. In winter, the climate in Sichuan Province is generally cold, and most areas are not comfortable. The comfortable areas in spring, autumn and winter are mostly concentrated in the Sichuan Basin. (2) Altitude has a great influence on climate comfort. The comprehensive climate comfort index after altitude correction generally increases from plateau mountains to basins, that is, the human body feels gradually comfortable from high altitude to low altitude. Wanyuan, Dazhou is the most comfortable area for human body in spring, summer and autumn in Sichuan Province. (3) There are significant differences in the influencing factors of climate comfort in different seasons, and appropriate physical factors must be selected to construct the prediction model.