Abstract: Based on the meteorological data and DEM data from 1991 to 2020, the effects of heat, moisture, light, topography, soil and other ecological climate factors on the growth and development of mulberry in Gaoxian County were analyzed systematically. Combined with the actual production, the high impact factor was selected as the index, GIS technology and set optimization method were used to divide the ecological climate suitability of mulberry in Gaoxian County. The results showed that the climatic conditions of mulberry in Gaoxian were generally suitable and had certain advantages. The main factors affecting mulberry cultivation were heat conditions and topographic slope. The most suitable area was mainly distributed in the valley area of Baqiu River below 500m, which was suitable for large-scale development of sericulture. The suitable areas are mainly distributed in hilly areas with an elevation of 500~700m, and the sericulture industry should be moderately developed. The sub-suitable areas are mainly distributed in low mountainous areas with altitude of 700~1000m, which can be used as supplementary production areas of mulberry leaves. Mulberry trees are not suitable for cultivation in mountainous areas with altitude above 1000m or terrain slope above 30°.