Abstract: According to the mean seasonal and annual temperature and precipitation from Nielamu and Dingri meteorological stations in the periods of 1967~2019, the variability of temperature and precipitation and their trends are analyzed in the Mount Qomolangma region. The biggest fluctuation of precipitation occured in winter on the seasonal scale, the mean annual temperature showed a wavelike decrease change before 1997 and a wavelike increase change after 1997, the mean seasonal and annual temperature are increased with the increasing of age. There is an increasing trend in mean seasonal and annual temperatures during this period in the Mount Qomolangma region, and the increasing trends in winter seem more significant than those in the other three seasons. The research in this paper showed the seasonal and annual precipitation are no obvious variation in the Mount Qomolangma region. On the other hand, there is obvious local change characteristics for temperature and precipitation in the Mount Qomolangma region. The results of this study would be helpful for the understanding of the climatic characteristics on the Tibetan Plateau, and it could provide a reference for the Second Tibetan Plateau Scientific Expedition and Research (STEP).